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Conclusions Nrf2 is a master regulator of several protective stress response pathways and it is not surprising that it became a highly competitive target for pharmacological modulation (Cuadrado et al

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For instance, topical applications often require higher concentrations at the site of action compared to injected methods, which bypass first-pass metabolism

Plant J 32:329342 Rouhier N, Lemaire S, Jacquot J-P (2008) The role of glutathione in photosynthetic organisms: emerging functions for glutaredoxins and glutathionylation

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